Peptide Glossary

Amino acids are organic molecules that join together in a definite order to form peptides and proteins. Various combinations of amino acids affect the structure of the peptide molecule.

An analytical assessment involves laboratory methods employed in assessing attributes like identity, composition, purity, or stability under controlled conditions.

Reference materials can be utilised in laboratory testing methods for calibration purposes and comparison during the analysis process.

Batch identifiers are unique codes allocated to a particular batch of products produced. Batch records aid in traceability, review of documents, and analysis of records.

Binding interaction involves the relationship between a peptide and other molecular structure, including receptors, enzymes, or protein targets, in the course of laboratory experimentation.

Buffers are laboratory solutions utilised for the purpose of maintaining the required pH levels during analytical processes.

CAS number refers to a numeric code assigned to a chemical compound for the purpose of identification in scientific and lab records.

Certificate of analysis refers to a batch-related analytical report that could have information on purity, molecular identity references, analytical methods used and batch related lab data.

HPLC (High Performance Liquid Chromatography) is an example of chromatographic technique applied to separate and analyse the components in a sample during an analysis process.

Degradation means the alteration that can happen in a peptide as a result of certain environmental factors such as moisture, temperature, or even light.

In relation to chromatography, elution is the process of separation of sample components during the analytical procedure.

Endotoxin testing may be a component of the analytical review process depending on the desired laboratory system and investigational requirements.

Freeze-drying, which is also referred to as lyophilisation, is a process that involves the removal of moisture from peptide material to facilitate stability during manipulation and storage.

GMP stands for Good Manufacturing Practice and relates to systematic manufacturing and quality control practices undertaken in regulated production facilities. The materials used in research might or might not be produced using GMP-certified facilities.

In lab environments, the half-life can be described as the reduction of a compound within a certain period or the stability of the compound.

HPLC purity determination is done to check the amount of the main peptide compound compared to other detected impurities.

Identity testing techniques are applied to ensure that a peptide is consistent with its anticipated molecular structure.

Impurities include any substances that are detected in the sample apart from the targeted substance being tested.

Lyophilisation is the scientific name for freeze-drying processes often employed in the manufacture of peptides and storage of laboratory materials.

Mass spectrometry is an analytical technique that helps in assessing the properties of molecules based on their mass-to-charge ratio.

The molecular mass is the calculated mass of the amino acid composition of a peptide sequence.

A peptide bond is the chemical bond that connects the amino acids in a peptide structure.

The characterisation process may involve the use of techniques for analysing the identity, purity, composition, or structure of peptides.

A peptide is an arrangement of amino acids bonded by peptide bonds into a molecular structure which is usually analysed in laboratories.

A peptide library entails a group of peptide structures used in comparative investigations.

Peptide synthesis is a laboratory process that involves the controlled formation of peptide molecules through the use of amino acids.

Percentage purity is the degree of the main component present within a substance after undergoing analysis through HPLC analysis.

Reconstitution is the term used to describe laboratory preparation processes carried out using already lyophilised products before their investigation usage.

The acronym RUO means that the material is meant for laboratory investigation only and should not be used on humans or animals.

Retention time is the time taken by a compound to travel through the chromatography process when carrying out an analysis.

Sequence verification testing is performed to determine whether the amino acid sequence of a peptide corresponds to structural expectations.

Solubility is a measure of how easily a peptide will dissolve in a chosen solvent in the laboratory setting.

Stability testing determines the behaviour of peptides under conditions such as time, temperature, humidity, or environment.

Storage requirements are instructions on the conditions that should be provided for maintaining the stability of a peptide.

TGA is the name of the Australian regulating body that oversees therapeutic goods and their regulatory framework.

USP is the name used for published standards for quality and testing of pharmaceutical and laboratory materials.